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doi: 10.1159/000064525 25 KangussuLMAlmeida-SantosAFBaderMAleninaNFontesMAPSantosRASet al

Comput Struct Biotechnol J

These numbers reflect reported laboratory practice only and are intended strictly for research use, not human use

ICIs work by blocking the interactions between immune checkpoints such as CTL-associated protein 4 (CTLA-4), programmed cell death-1 (PD-1), and programmed cell death ligand-1 (PD-L1) and their ligands, which releases the inhibitory brakes of T cells and results in the robust activation of immune responses (Fig